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[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Fläring U., Rooyackers O., Wernerman J., Hammarqvist F

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While classical gene mutations are region-limited, epimutations often occur early in cancer development and have a genome-wide impact, boosting on the one hand the expression of cell survival genes or proto-oncogenes and deactivating on the other hand tumor suppressor genes (TSGs), DNA repair mechanisms as well as cell division brakes, thus leading to carcinogenesis (Schnekenburger and Diederich, 2012